The authors were not particularly surprised by the reduction in actual melatonin concentrations in many melatonin products due to known degradation or stability issues.7 However, they found the excessive melatonin content confusing and questioned whether an excessive amount of melatonin had been added to ensure that the product met the label claim. The researchers refused to name the products or manufacturers, which was probably wise because none of them stood out (avoiding arguments and lawsuits from manufacturers). The National Agency for Health, Food, Environmental and Occupational Safety (ANSES) in France said pregnant and lactating women should not consume melatonin in supplement form. You want to buy melatonin and you are still wondering what to pay attention to? Here you can learn all about the effect, application and dosage of the sleep hormone. It would make sense to replicate this study with over-the-counter melatonin products sold in the U.S., as their use continues to increase unchecked. We (and our patients) must remember that oral melatonin is absorbed quickly, with peaks of 20 to 30 minutes after oral ingestion (Tmax), but a very short elimination half-life (t1/2) of only 40 to 60 min.21 Melatonin works best as a chronobiotic, not hypnotic. A recent meta-analysis of 17 studies (mostly healthy subjects) showed that melatonin reduced sleep latency by an average of 4 minutes, increased sleep efficiency by 2.2%, and increased sleep duration by 12.8 minutes. all values are modest at best.22 Does this make German products worse? On the contrary! Especially exciting: a meta-study from the American elite university MIT was able to confirm the positive effect of melatonin at low doses on sleep.  In addition, Professor Richard Wurtman and other scientists and researchers reviewed a total of 17 studies on melatonin. The result was an incredibly important discovery for any biohacker: we celebrate the medical benefits of melatonin as a chronobiotic for specific patient populations, sleep disorders, and medical conditions.
The same is true here. Low doses of 0.3 to 1 mg of melatonin are already effective and should therefore be considered. In Spain and Italy, melatonin is approved in dietary supplements up to 1 mg per day. In some countries, including Denmark and the Czech Republic, melatonin is banned in dietary supplements. However, if melatonin is taken at the wrong time or at too high a dose, it can have the opposite effect. Children and pregnant women (including extended women) should not take the capsules. Our sleep hormone, melatonin, plays the most important role when it comes to sleep. In this article you will learn exactly what melatonin is, what effect it has on your body and where you can buy melatonin in Germany without a prescription. In order to protect the population from health risks and combat illicit drug trafficking, the trade in pharmaceuticals and narcotics is strictly regulated in Germany.
Here`s what you need to consider if you are in possession of medication during your trip. Many people buy melatonin, the natural sleep aid, because it can help relieve subjectively perceived feelings of jet lag. Especially on long-haul flights and the resulting jet lag, or for shift workers who often have to work at night, the normal sleep-wake rhythm becomes out of sync. Be careful, now it becomes even more complex: this cycle is controlled by another hormone, the so-called happiness hormone “serotonin”. Serotonin is the precursor of melatonin and therefore the basis of the sleep hormone. At the same time, this is where the first hack comes into play for you. You can affect the amount of serotonin in your body! As the title suggests, I am very unhappy with the melatonin situation when I hear such good reviews about it. 🙁 Does anyone have an alternative? In this issue of the Journal of Clinical Sleep Medicine, Erland and Saxena systematically analyzed actual melatonin levels (and the presence of impurities) in 31 melatonin supplements purchased from grocery stores and dispensaries in a city in Canada (before the use of over-the-counter drugs nationwide was banned in Canada). Their findings herald what could also be true in over-the-counter melatonin supplements marketed in the United States. Melatonin levels ranged from a scandalous -83% to +478% of labeled melatonin and 70% had a melatonin concentration ≤ 10% of what was claimed. Even worse, melatonin levels varied by up to 465% between batches of the same product.3 Small doses of 0.3 mg to 1 mg of melatonin administered orally are particularly effective and can help reduce the time it takes to fall asleep, ensuring a good night`s sleep and a better feeling in the morning.
Higher doses of melatonin, on the other hand, appear to be counterproductive. Data from an American sleep-tracking company showed that lack of sleep can also have much worse physical effects in the long run.  Are you beginning to understand why good sleep is so important? It`s good and it`s much better. Your sleep, or the hormone melatonin, which is responsible for your sleep-wake cycle, can easily be “manipulated.” The opinion of ANSES No. 2016-SA-0209 further recommends favoring simple formulations that do not combine melatonin with other ingredients and avoiding the simultaneous use of several supplements to limit the risk of interactions. Does the dose of melatonin obtained play a role? Lower doses may be ineffective, overnight dose variability is interpreted as a secondary failure of efficacy, and higher doses could lead to unpleasant/unexpected side effects, especially for those who are sensitive to them or taking medications that interact with melatonin, and in those who are pregnant, allergic to impurities, or have diabetes/prediabetes. The long-term effects of melatonin supplementation on prepubertal children remain unknown.4,5 Why? We believe that 1 mg of melatonin combined with sleep advice is the most effective way to fall asleep and sleep well. SLEEP contains 1 mg of melatonin per daily dose as well as other herbal substances. This makes it one of the supplements that can be purchased without a prescription.
SLEEP is produced and tested safely in Germany. It does not contain any ingredients of animal origin. Therefore, it is 100% vegan. In addition to its effects on the biological clock, melatonin has other properties: modulation of mood and the immune system, regulation of body temperature and intestinal function. The more natural and vitamin-rich the food, the better it is for the balance of your intestines and therefore for a restful sleep. Foods that contain melatonin are pistachios and cherries. However, it is also important when you eat. If we eat late and, especially before going to bed, consume a lot of carbohydrates, insulin levels increase massively.
In Belgium and Germany, products containing 0.3 mg of melatonin or more per day are considered medicinal products because of their pharmacological activity. Another Harvard University study found that devices in the bedroom that emit blue light can disrupt the sleep-wake cycle and reduce the number of REM phases. Blue light inhibits melatonin production and promotes cortisol production. Drugs, extemporaneous preparations and dietary supplements use the hormone melatonin, whose physiological function is, among other things, to promote sleep. Lights out is the motto. Did you know that your skin contains light receptors that send signals to your brain? That`s why it`s not enough to wear a sleep mask that covers your eyes. It is best to sleep in the darkest room possible. Studies from Harvard University have shown that melatonin levels in the blood can be up to 50% lower when you sleep in a bright room. BRAINEFFECT HACK: Don`t want to take melatonin tablets or capsules, but dose your sleep individually? Then our innovative BRAINEFFECT SLEEP SPRAY with melatonin is your way of dosing melatonin individually. The oral spray helps you turn off your head at night and fall asleep better with melatonin. Both products have been tested and are on the Cologne list. Therefore, many elite athletes and clubs use both products.
Grigg-Damberger MM, Yanakieva D. Poor quality control of over-the-counter melatonin: What they say is often not what you get. 2017;13(2):163-165. 60 minutes before bedtime, increases steadily and decreases sharply about 90-180 minutes before waking up. Higher supplementation of the hormone with, for example, 5 mg accelerates this process, so that one wakes up earlier and suffers from the perceived recovery.